Symposium Program

7:00

UK NEQAS: History and Impact Barbara De la Salle.

7:05

EQA Uncovers Haemostasis Assay Limitations Chris Reilly-Stitt.

7:20

NPM1 False Positives in Acute Myeloid Leukaemia: Causes, Consequences and Controls Stuart Scott.

7:35

Reading Between the Lines: How EQA Helps to Rewrite Instructions to Ensure Patient Safety Bashori Rahman, Yvonne Hector.

7:50

Panel Q&A .

8:00

Welcome Remarks .

8:10

Laboratory & Medicine 2.1: Care For What You Wish For Marcel Levi. AmsterdamUMC

8:40

Hemoglobinopathies and Molecular Diagnosis Cornelis L. Harteveld. Associate Professor at the Dept. of Clinical Genetics, Leiden University Medical Center

9:10

Laboratory diagnosis, monitoring and management of PNH Morag Griffin. St James Hospital, Leeds, UK

10:15

Limits of Haemostasis Assays Kieron Hickey. Sheffield Haemophilia and Thrombosis Centre.

10:45

Combining functional tests and genetics for inherited thrombophilia diagnosis Christine Van Laer. Department of Laboratory Medicine, AZ Groeninge, Kortrijk, Belgium

11:15

Developmental Hemostasis Ulrike Nowak-Goettl. Institute of Clinical Chemistry, University Hospital Kiel, Germany

10:15

Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party Jacqueline Cloos. AmsterdamUMC

10:45

LSC MRD in AML Veronika Ecker. MLL Munich Leukemia Laboratory GmbH (MLL)

11:15

Flow cytometry detection of MRD in myeloma: update Bruno Paiva. Clinica Universidad de Navarra

1:15

Berend Houwen Lecture:Laboratory Monitoring of Unfractionated Heparin Treatments – Unanswered Issues Pierre Toulon. Nice University Hospital, Dept of Hematology France

2:00

Wallace H Coulter Lecture:Investigator-Led Research to Improve the Diagnostic Assessment of Platelet Function Disorders: Reflections on the Challenges and Rewards Catherine Hayward. McMaster University

3:30

Blood rheology biomarkers in Sickle Cell Disease Minke Rab. Erasmus University Medical Center Rotterdam

4:00

Laboratory diagnosis of pyruvate kinase deficiency Archana Agarwal. University of Utah/ARUP Laboratories

4:30

Implementation of AI algorithms for laboratory workup of microcytic anemias Veroniki Komninaka. G.Gennimatas, General Hospital, Athens, Greece

3:30

Machine learning, anti-cancer immunotherapy in hematology Pieter Meysman. University of Antwerp

4:00

Single-Cell Analysis, TCR, Functional Diversity Paul Klenerman. University of Oxford

4:30

Whole Genome Analysis James Allan. Newcastle University

100

New Approach on Testing Platelet Function in Clinical Practise Mohammad M Algahtani. Security Forces Hospital Makkah, MAKKAH, Saudi Arabia

101

Integrating Monocyte Distribution Width (MDW) into Routine CBC Reporting for Early Sepsis Detection: A Systematic Review Mohamed Al Zaabi MD, FRCPath1, Amal Al Jabri MD, FRCPath2. 1Department of Hematology and Blood Bank, Khoula Hospital, Muscat Oman.2Department of Microbiology, Khoula Hospital, Muscat Oman

103

Reticulocytes performances and study of flag of clinical usefulness, sthemA 601 evaluation N. Banh1, B. Butt1, C. Doinel1, V. Nadal1, T. Nguyen1, D. Paulin1, C. Ranaivoarimalala1, S. Melin2E. Tournier2, Dr. I. Habes Lenouar1, Dr. C. Brumpt1. 1Hematology laboratory, University Hospital LariboisiAure, Paris France.2Diagnostica Stago, AsniAures sur Seine France

104

Evaluation of Flagging Performance for Pathological Cell Detection on the Mindray BC-7800 versus Siemens ADVIA 2120i Using Microscopy as the Reference Method Vincenzo De Iuliis, Mario Forcella, Cristina Di Saverio, Giusy Bove, Sofia Chiatamone Ranieri. Department of Clinical Pathology, G. Mazzini Civil Hospital, Teramo, Italy

106

Hematologic Biomarkers to Support Procalcitonin Stewardship in Intensive Care Unit: Monocyte Distribution Width and CBC-Derived Ratios Laura GarcAsa1, Sandra Ramos2, JesAos A. A2, Antonia M. Mayol1, Isabel AlbalAi1, JosAc C. FrAsas2, NicolAis SuAirez2. 1Department of Laboratory Medicine, Hospital Juaneda Miramar, Palma de Mallorca, Spain.2Intensive Care Unit, Hospital Juaneda Miramar, Palma de Mallorca, Spain

107

Use of Monocyte Distribution Width (MDW) for the Prediction of Blood Culture Positivity in Emergency Department Patients Elena Giberti1, Irene Venturelli2, Mario Sarti2, Giovanni Riva1, Vincenzo Nasillo1, Valentina Pecoraro1, Manuela Varani1Tommaso Fasano1. 1Laboratory Medicine Unit, AUSL Modena, Modena, Italy.2Microbiology Unit, AOU Modena, Modena, Italy

108

Routine Blood Count–Derived Markers in Patients with Mycosis Fungoides Berrak Guven1, Murat Can1, Nur Cansu Erken1, Emel Hazinedar2. 1Department of Biochemistry, BA¼lent Ecevit University, Zonguldak Turkey.2Department of Dermatology, BA¼lent Ecevit University, Zonguldak Turkey

109

Hematologic Changes Associated with Measles Infection: A Retrospective Chart Review Faramarz Jabbari-Zadeh1, Michael Samuel2, Benjamin Hedley2, Ana Cabrera2, Johan Delport2, Benjamin Chin-Yee2, 3, Cyrus Hsia2, 3. 1Western University, Schulich School of Medicine a Dentistry, Department of Medicine, London Health Sciences Centre, London, ON, Canada.2Western University, Schulich School of Medicine a Dentistry, Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, ON, Canada.3Western University, Schulich School of Medicine a Dentistry, Division of Hematology, Department of Medicine, London Health Sciences Centre, London, ON, Canada

110

Differential Responses of Peripheral Blood Monocytes From Patients With Alzheimer’s Disease to Lipopolysaccharide and Amyloid-β Stimulation hye ryoun kim, Soonchul Hong. Chung-Ang University College of Medicine, Seoul, Korea

111

A Substantial Proportion of Body Fluid Samples Fall Below the Limit of Quantification: Implications for Automated Hematology Analyzer Use by Body Fluid Type Young Kyung Lee1, 2, Ju Yeon Shim2, Youngmin Kim2. 1Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon, South Korea.2Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea

112

Scatterplot analysis as a potential guide for peripheral blood smear review in samples with low schistocyte counts Maria del Mar Meijon1, Beatriz Astibia1, Sandra Lopez1, Fernando Martin1, Miguel Piris1, Juan Marquet1, Javier Lopez1, Jesus Villarrubia2, Gemma Moreno1. 1Department of Hematology, Hospital Universitario Ramon y Cajal-IRYCIS, Madrid, Spain.2Laboratorio Central de Madrid, UR Salud UTE, Madrid, Spain

113

“Infected RBC flag” on Mindray CAL8000 leading to development of a novel screening algorithm for prevention of donor-derived malaria in Live-Donor Liver Transplantation (LDLT) patients. ADITI MITTAL1, ANIL HANDOO1, TINA DADU1, PRATYUSH MISHRA1, ABHIDEEP CHAUDHARY2. 1Dept of Hematology, BLK-Max Super Speciality Hospital, NEW DELHI, India.2Dept of HPB Surgery a Liver Transplantation, BLK-Max Super Speciality Hospital, NEW DELHI, India

114

NT-proBNP as a Biomarker in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma: A Retrospective Analysis Eun-Hee Nah1, Yong Jun Choi2, Jooheon Park2, Ha Jin Lim3, Yong Jun Kwon3, Myung Geun Shin2. 1MEDIcheck LAB, Korea Association of Health Promotion, Seoul South Korea.2Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, Hwasun South Korea.3Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju South Korea

115

Comparison of Neutrophil-Lymphocyte Ratio, Neutrophil-Monocyte Ratio, Pan-Immune-Inflammatory Value, C-Reactive Protein, and Procalcitonin in Determining Prognosis of Neonatal Sepsis Asvin Nurulita1, 2, Mansyur Arif1, 2, Arifin Seweng2, Sakina Usman2. 1dr. Wahidin Sudirohusodo Hospital, Makassar Indonesia.2Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar Indonesia

116

Autoverification for Optimizing CBC Workflow and Laboratory Efficiency Karan Paisooksantivatana. Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

117

Comparison of Blood Film Review Rates between Atellica HEMA and ADVIA 2120i Hematology Analyzers Sharon Radford1, Apostolia Barmpoudi1, Andrew Smith1Graham Gibbs2. 1Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.2Siemens Healthcare Laboratory Diagnostics, Camberley, United Kingdom

118

Evaluation of Analytical Precision of Monocyte Distribution Width (MDW) in Hospitalized and Emergency Department Patients. Jennifer Rodriguez-Dominguez, Alba Leis-Sestayo, Isabel Aparicio-Calvente, Laura Jimenez-AApon, Cristian Morales-Indiano, Alicia Martinez-Iribarren. Laboratory department of medicine. Germans Trias i Pujol University Hospital, Badalona, Spain

119

First comparative analysis of the behavior of hematimetric biomarkers associated with sepsis (Neu-X, Neu-Y, and Mon-X) in adult ambulatory population versus Intensive Care patients in Montevideo, Uruguay (2024-2026). Lucila I Silva1, Cecilia Canessa1, Marco Alpuin2, Gabriela Chocho1, Macarena Acosta1, Miguel Lujan1, Ana K. Ambrosetti1, Jimena Viera1, Gabriela Geymonat1, Rafael Bertullo1, Mariela Luppi2. 1Medica Uruguaya (MUCAM), Montevideo Uruguay.2Biodiagnostico, Montevideo Uruguay

120

Performance evaluation of Mindray BC-6800 Plus versus Sysmex XN 1000 and DXH 800 hematology analyzers Sonya F. Soliman1, Mohamed Kamal2, Roxan Shafik1Mohamed Zaki1, Amr Hussein 1, Mai Abdelwahab1, Mohamed Ahmed1. 1Clinical Pathology Department, Children Cancer Hospital of Egypt, 57357, Cairo Egypt.2Clinical Research Department, Children Cancer Hospital of Egypt, 57357, Cairo Egypt

122

Evaluation of Complete Blood Count-derived ratios in Ischemic Stroke. A preliminary report Konstantina Tsioni1, Eftychia Nikolakopoulou2, Angeliki Karyoti1, Aristeidis Chalvantzis1, Marianthi Issa1, Aikaterini Karantani1, Dimitrios Komilis3Eleni Vagdatli1. 1Biopathology Laboratory, Hippokration General Hospital, Thessaloniki, Greece.2Biopathology Laboratory, Xanthi General Hospital, Xanthi, Xanthi, Greece.3Department of Environmental Engineering, Democritus University of Thrace, Xanthi, Greece

123

Dynamics of Hematological Parameters During Iron Therapy in Patients with Iron Deficiency Anemia and Latent Iron Deficiency Irina V Tyutlina1, Yuliana Y Agametova2Elena A Sukhacheva3. 1LLC qCenter for Laboratory Diagnosticsq, Novosibirsk, Russia.2Beckman Coulter Ltd., Moscow, Russia.3Beckman Coulter Eurocenter, Nyon, Switzerland

124

Predictive model based on Cell Population Data for 30 days -mortality in Community-acquired pneumonia Eloisa Urrechaga, Monica Fernandez, Ane Uranga, Urko Aguirre. Hospital Universitario Galdakao Usansolo, Galdakao, Spain

125

A comparative evaluation of domain-specific versus general-purpose large language models for complete blood count report interpretation Di Wang1, Donglan Yao2, Jianping Xiao2, Xiaosen Bian2, Xiaomei Zhang2Haoqing Jiang1. 1Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai China.2Hematology Product Development Department, Shenzhen Mindray Bio-Medical Electronics Co. Ltd, Shenzhen China

126

Leukopenia, Thrombocytopenia, and Beyond: Hematological Signatures of Dengue Infection in a Malaysian Cohort Shafini M. Yusoff1, 2, Marini Ramli1.2, Rosnah Bahar1, 2, Noor Haslina M Noor1, 2, Mohd Nazri Hassan1, 2, Zefarina Zulkafli1, 2. 1Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.2Hospital Pakar Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

127

Rapid Detection Parameter for Sepsis (RDPS): A Multiparameter Hematological Biomarker for the Early Diagnosis of Sepsis in Emergency Departments Xiaohe Zheng1, Weidong Chen2, Yating Zhao3, Shiyao Pan4, Liang Zhou4, Yan Liu4, Shihong Zhang1. 1Department of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou China.2Emergency Department, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou China.3Department of Laboratory Medicine, Nansha, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou China.4Department of Clinical Research a Medical Affairs, Shenzhen Mindray Bio-Medical Electronic Co., Ltd., Shenzhen China

128

Machine Learning-Based Early Screening of Myelodysplastic Syndromes Using Complete Blood Count Guoqing Zhu1, Juan Zhang2. 1Institute of Hematology a Blood Diseases Hospital, Chinese Academy of Medical Sciences a Peking Union Medical College, Tianjin, China.2Sichuan Academy of Medical Sciences a Sichuan Provincial Peoplea, Chengdu, China

129

Evaluation of Different Methods of Reporting and Interpretation of DRVVT Testing Zahra Al-Ghammari1, Muntadhar AL-Moosawi 2. 1Oman Medical Specialty Board, Muscat, Oman, Oman.2Cleveland Clinic, Abu Dhabi, UAE, United Arab Emirates

131

Haematological biomarkers: von Willebrand factor, ADAMTS13 and FvW/ADAMTS13 ratio in atrial fibrillation patients with or without ischemic stroke. Carlos Arean-Martinez1, Alan F Cano-Mendez2, Nallely Garcia-Larragoiti2, Larissa Herrera-RodrAsguez1, Martha Eva Viveros-Sandoval2. 1Servicio de CardiologAsa. Hospital General Miguel Silva, SSM, Morelia, Mexico.2Laboratorio de Hemostasia y BiologAsa Vascular. qIgnacio Chavezq School of Medicine, UMSNH., Morelia, Mexico

132

Validation of the Revohem™ FIB LRT Reagent on the CN-3000 Analyzer: Analytical Performance and Method Comparison Ivana Buttice, Anne-sophie Vandoorne, Samuel Vandooren, Jonathan Brauner, Phuong Ngyuen. Clinical laboratory CH EpiCURA, 7800 Ath Belgium

133

Characterizing Coagulation Dynamics in Hormonal Contraception Users Using Thromboelastography Stefania Coroneos1Regan Bucciol1, Yousra Tera1, 2, Maica Yunon3, Caroline Mwubaha3, 4, Maha Othman1, 2, 3. 1Queen's University, Kingston, ON, Canada.2Mansoura University, Mansoura, Egypt.3St. Lawrence College, Kingston, ON, Canada.4Infectious Disease Research Collaboration, Kampala, Uganda

134

Comparison of Different Interpretative Methods of Activated Partial Thromboplastin Time Immediate Mixing Test in Paediatric Patients Yee Zhe Heng, Qiu Yan Wong, Soh Hong Ang, Rebecca A. Barton, Joyce C. M. Lam. KK Women's and Children's Hospital, Singapore, Singapore

135

Evaluation of the Sysmex Automated Blood Coagulation Analyser CNTM-700: Precision Assessment and Comparative Analysis with the Automated Blood Coagulation Analyser Sysmex CNTM-6000. Kevin Horner 1, Kerensa Leeson 1, Irfan Patel 2, Seigo Munehisa 3, Sakayori Tasuku 3, Matsuno Eriko 3, Kieron Hickey 1, Steve Kitchen 1. 1Haemostasis Department, South Yorkshire and Bassetlaw Pathology Royal Hallamshire Hospital, Sheffield, United Kingdom.2Sysmex UK Ltd, Milton Keynes, United Kingdom.3Sysmex Corporation, Kobe, Japan

136

Identification of Underlying Genetic Variants in Sporadic Factor VIII Deficiency Through Precision Genomics Tehmina Khan1, Shahla Sohail2, Masood Fareed Malik3, Arshi Naz4. 1IMU University, Kuala Lumpur, Malaysia.2Shahla Sohail, Lahore, Pakistan.3Masood Fareed malik, Lahore, Pakistan.4Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

137

Modern Hemostasis Testing: Comparison of the Sysmex CS-2500 and CN-3000 analyzers’ impact on Laboratory Efficiency XJ Koa, HM Zulkifli, N RuzlanNA Kamaludin , TC Aw. Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore, Singapore

138

Comparative Assessment of the Sysmex Automated Blood Coagulation Analyser CNTM-700 with the Automated Blood Coagulation Analyser Sysmex CATM-660 Kerensa Leeson 1Kevin Horner 1, Irfan Patel 2, Seigo Munehisa 3, Sakayori Tasuku 3, Matsuno Eriko 3, Kieron Hickey 1, Steve Kitchen 1. 1Haemostasis Department, South Yorkshire and Bassetlaw Pathology, Royal Hallamshire Hospital, Sheffield, United Kingdom.2Sysmex UK Ltd, Milton Keynes, United Kingdom.3Sysmex Corporation, Kobe, Japan

139

Procoagulant Shift Induced by Oral Contraceptives in the STGenesia® Thrombin Generation Assay: A Distinct Subgroup in an Ongoing Local Reference Range Study in Portugal Tiago LuAss1, Dalila Marques1, Joana Rita1, Ana Campos1, Paula Leal2, Goncalo Orfao1, Nelya Syamro1, Olena Lavrukhina1, Marco Matias1, Jorge Tomaz1. 1Congenital Coagulopathies Reference Centre-RamA³n Salvado, Thrombosis and Haemostasis Unit, Blood Bank and Transfusion Medicine, Coimbra, Portugal.2Resident Pharmacist in Clinical Pathology, Coimbra, Portugal

140

Impact of Cartridge Lot-to-Lot Variability on Extrinsic Thromboelastometry Clotting Time: Risk of Misinterpretation Across Clinical Decision Thresholds Hoyoung Moon1, Taekyun Kim1, Mijeong Kim1, Daehyun Chu1, 2, Miyoung Kim1, 2, Young-Uk Cho1, 2, Seongsoo Jang1, 2. 1Department of Laboratory Medicine, Asan Medical Center, Seoul, Korea.2Department of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea, Seoul, Korea

141

Machine Learning-Based Detection of In Vitro Activated Coagulation Using APTT Clotting Curves Keisuke Nishi1, Akiyo Kawamoto1, Eri Adachi1, Takesh Suzuki1, Nobuo Arai1, Hiroshi Kurono1, Kaho Kurashima2, 3, Itsuko Sato3, Tomoya Fukuoka3, 4, Ruri Kono2, 3, Kohei Morimoto2, Yoshinori Nakamura2, Yoshiharu Miyata2, 5, Takamitsu Imanishi3, Yoshihiko Yano3, Hiroshi Matsuoka2. 1Sysmex Corporation, Kobe, Hyogo, Japan.2Kobe University Hospital Bioresource Center, Kobe, Hyogo, Japan.3Department of Clinical Laboratory, Kobe University Hospital, Kobe, Hyogo, Japan.4Department of Clinical Laboratory Science, Tenri University, Tenri, Nara, Japan.5Department of Artificial Intelligence and Digital Health Science, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

142

Method Comparison of the Revohem Anti-Xa LRT assay Compared to Other Commercial Reagents – Monitoring of Unfractionated and Low Molecular Weight Heparin Thomas Pitchford1, Kieron Hickey1, Steve Kitchen1, Tasuka Sakayori2, Sho Shinohara3, Miyu Kitagami2. 1Haemostasis Department, South Yorkshire and Bassetlaw Pathology, Royal Hallamshire Hospital, Sheffield, United Kingdom.2Sysmex Corporation, Kobe, Japan.3Hyphen BioMed, Neuville-sur-Oise, France

143

Introduction of a new paired reagent combination for lupus anticoagulant assays by activated partial thromboplastin time Jude Platton1, 2, Minal Dave1, 2, Anne Horton1, 2Katarzyna Kniola1, 2, Nada Yartey1, 2, Sean Platton3. 1Haemostasis Laboratory, Royal London Hospital, London, United Kingdom.2National Health Service East and South East London Pathology Partnership, London, United Kingdom.3The Royal London Hospital Haemophilia Centre, London, United Kingdom

144

Performance Evaluation of RevohemTM vWF Ag Reagent Featuring an Extended Measuring Range for High-Level von Willebrand Factor Antigen Hayato Saito1, Takahiko Bando1, Tasuku Sakayori1, Sho Shinohara2, Sophie Molton2, Claire Dunois2, Kaori Otake1. 1Sysmex Corporation, Kobe Japan.2Hyphen BioMed, Neuville-sur-Oise France

145

Discrepant results in FXIII assays due to FXIII replacement therapy? Sanne Vanthourenhout, Katrien M.J. Devreese. Ghent university hospital, Ghent, Belgium

146

TRBC1 Flow Cytometry in the Assessment of T-Cell Clonality: A Single-Center Experience Tanja Antunovic1, Ivana Milasevic1, Enisa Zaric2. 1Centre for Clinical Laboratory Diagnostic, Clinical Centre of Montenegro, Podgorica.2Centre for Hematology, Clinic for Internal Medicine, Clinical Centre of Montenegro, Podgorica

147

Optimization of Immunophenotypic Evaluation of Myelodysplastic Neoplasms by Flow Cytometry: A 2-Tube, 13-Color PanelOptimization of Immunophenotypic Evaluation of Myelodysplastic Neoplasms by Flow Cytometry: A 2-Tube, 13-Color Panel Laiz C Bento, Flavia A Sousa, Priscila C Myamoto, Barbara F Bueno, Elizabeth X Souto, Nydia S Bacal. Einstein Hospital Israelita, SApo Paulo, Brazil

148

Real-world data of T-cell clones of uncertain significance: an observational study of prevalence and immunophenotypic characteristics in a large community laboratory Song Chen1, Sophie Suke1, Brydon Panozzo1, 2, Ben Hawkins1, Sophie Sanguine1. 1Australian Clinical Labs, Melbourne, Australia.2Alfred Health, Melbourne, Australia

149

Simple flow cytometry assay uncovers AR-CGD missed by whole exome sequencing: a multi-specialty diagnostic odyssey Gabrielle Dammers1, Priyanka Pandey1, Leslie Koutoufaris1, Jeri Dorsey1, Michele Paessler1, 2, Soma Jyonouchi1, 3. 1Clinical Immunology Lab, Abramson Research Center, Childrena, Philadelphia, PA, USA.2Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.3Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

150

Flow cytometric backbone panels for flexible antigen quantification on lymphoid or myeloid populations Sarah Klapproth1, Angelika J. Fischbeck1, Manja Jargosch1, Vasco Dos Reis Goncalves2, Sabrina Mueller2, Chrysanthi Tsamadou1, Wolfgang Kern1, Veronika Ecker1. 1MLL Munich Leukemia Laboratory, MA¼nchen Germany.2T-CRUX GmbH, WA¼rzburg Germany

151

Minimal expression of CD300e (IREM-2) in Paroxysmal Nocturnal Hemoglobinuria (PNH) monocyte clones – A novel GPI-anchored or GPI-linked receptor in monocytes? Angeliki Kotsiafti1, Christina Karela1, Evangelia Kouvata2, Georgios Oudatzis1, Maroula Milaiou1, Aikaterini Mandaraka1, Anna Pigaditou3, Styliani Kokoris4, Nikolaos Giannakoulas2, Eleni Gavriilaki5, Paraskevi Vasileiou6, Elisavet Grouzi7, Georgios Paterakis1. 1Department of Immunology, Athens General Hospital a, Athens, Greece.2Department of Hematology, University Hospital of Larisa, Larisa, Greece.3Aa, Athens, Greece.4Laboratory of Hematology and Blood Bank Unit Athens, Greece.52nd Propedeutic Department of Internal Medicine AUTH, Thessaloniki, Greece.6AlFlowdiagnosisAr Diagnostic Center, Athens, Greece.7Transfusion Service and Clinical Haemostasis, qSt Savvasq Oncology Hospital, Athens, Greece

152

Prognostic impact of hematogones and CD34+ myeloblasts in bone marrow of B-cell acute lymphoblastic leukemia patients without measurable residual disease post-induction: A single-center cohort study Prabhu Manivannan1, Gifta Catharine1, Smita Kayal2. 1Department of Pathology, JIPMER, Puducherry, India.2Department of Medical Oncology, JIPMER, Puducherry, India

153

Flow-Cytometric Profiling of Leukocyte Markers and Their Association with SOFA-Based Severity and Mortality in Sepsis Shruti Mishra1, Rohit Daga2, Kailash Kumar2, Nilesh Kumar2. 1Bone Marrow Transplantation and Stem Cell Research Centre, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.2Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

155

Development and Preliminary Validation of a 10-Color Multiparameter Flow Cytometry Panel for Acute Myeloid Leukemia Najwan Salih Nima1Renjie Liang2, Libing Xu2, Xin Guo3, Xin Chen3. 1Medical City, Baghdad, Iraq.2Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen, China.3Henan Caprico Biotechnology Co., Ltd., Henan, China

156

Expanding Diagnostic Insights: EMA Binding Assay and NGS in Red Cell Membrane Pathologies Priyanka Pandey1, Marilyn Li1, 2, 3Michele Paessler1, 3. 1Department of Pathology and Laboratory Medicine, Childrena, Philadelphia, PA, USA.2Department of Pediatrics, Childrena, Philadelphia, PA, USA.3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

157

Security Guards of Immune System: A Flow Cytometric Study of Regulatory T cells in Paediatric Idiopathic Nephrotic Syndrome SWATI SHARMA1, P LALITA JYOTSNA1, SHAILAJA SHUKLA1, ABHIJEET SAHA2. 1Department of Pathology, Lady Hardinge Medical College, New Delhi, India.2Department of Paediatrics, Lady Hardinge Medical College, New Delhi, India

158

Autoimmune Lympho-Proliferative Syndrome Unmasked by Detection of a Rare FAS Splice Acceptor Variant on an Expanded Next-Generation Sequencing Hematologic Malignancy Panel Daniel C. Akuma, Emily Ling-Lin Pai, Olga O. Pozdnyakova, Guang Yang. Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

159

Detection of FLT3 mutations in acute myeloid leukemia using next-generation sequencing, fragment analysis and direct sequencing Soon Hee Chang, Sang Mook Kim, Soong Ki Roh, Eun Jin Kim, Yu Kung Kim, Dong Il Won, Jang Soo Suh. Kyungpook National University, Daegu, South Korea

160

Ultra-Sensitive superRCA Assay Enables Detection of KIT D816V in Systemic Mastocytosis Patients with Low VAF Andrew S. Dixon1, Natalia Sigal1, Erik Kish-Trier1, Mark Rosenzweig2, Guang Yang2, Rentian Wu2, Rachel L. Erlich2, Lei Chen3, Sara Bodbin3, Tracy I. George1, Leo Lin1, Peng Li1. 1ARUP Laboratories, Salt Lake City, UT, USA.2Blueprint Medicines, Cambridge, MA, USA.3Rarity Bioscience, Uppsala, Sweden

161

An Aggressive Disease: Pediatric BCR::ABL1 Positive T-Lymphoblastic Leukemia Asma Al Jahwari1, Nawal Al Mashaykhi2, Fatma Al Bulushi1, Suha Al lawati1, Mohammed Al Rawahi3, Yasser Wali4, Amr Dahdouh2, Abdulhakim Al-rawas2, Halima Al-shehhi5. 1Department of Hematology, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman.2Department of Child Health, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman.3Department of Hematology, College of Medicine, Sultan Qaboos University, Muscat, Oman.4Department of Child Health, College of Medicine, Sultan Qaboos University, Muscat, Oman.5Department of Genetics, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman

163

Detection of measurable residual disease by measurement of WT1 expression in acute myeloid leukemia patients Perapon Junturat1, Adcharee Kongruang1, Dollawat Sae-chua1, Kwannapa Aiyarapong1, Takol Chareonsirisuthigul1, Budsaba Rerkamnuaychoke1, Sasivimol Rattanasiri2, Chanatpon Aonnuam2, Orathai Munggaranonchai2, Teerapong Siriboonpiputtana1. 1Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.2Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

164

NGS-Based Comparative Analysis of Multiple Myeloma According to 1q21Gain Jung Ah Kwon1, Jong Kwon Lee2, Seong Gyu Yun2, Dongjin Shin2. 1Korea University guro hospital, seoul, Korea.2Korea university anam hospital, seoul, Korea

165

Development of a highly sensitive real-time qPCR reagent for the screening of VEXAS syndrome Miwa Matsubara, Mayu Ikeda, Shota Nakada, Yuki Namba, Hikaru Hattori, Yuji Izumisawa. Sysmex Corporation, Kobe, Japan

166

Refining BALL Diagnostics: Unlocking RNASeq’s Potential Against the FISH Gold Standard Manja Meggendorfer, Torsten Haferlach, Wencke Walter. MLL Munich Leukemia Laboratory, Munich, Germany

167

Routine TP53 testing and clinical impact in DLBCL: an open question Veronika Navrkalova1, 2, 3, Andrea Mareckova1, Vaclav Kubes4, Lenka Radova2, 3, Michael Doubek1, 2, 3, Sarka Pospisilova1, 2, 3, Jana Kotaskova1, 3. 1Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.2Central European Institute of Technology (CEITEC), Center of Molecular Medicine, Masaryk University, Brno, Czech Republic.3Department of Medical Genetics and Genomics, Faculty of Medicine, Masaryk University and University Hospital Brno, Brno, Czech Republic.4Department of Pathology, University Hospital Brno, Brno, Czech Republic

170

β-GLOBIN GENE MUTATIONS IN β-THALASSAEMIA PATIENTS ACROSS CAMBODIA AND MALAYSIA zefarina zulkafli1, 4, Razan Hayati Zulkeflee1, 4, Rosnah Bahar1, 4, Rosline Hassan1, 4, Zilfalil Alwi1, 4, Muhammad Faris Danish Syukri3, Srey Viso2, Chean Sophal2. 1Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.2National Pediatric Hospital, Phnom Penh, Cambodia.3School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia.4Hospital Pakar Universiti Sains Malaysia, Kubang Kerian, Malaysia

171

Early detection of acute megakaryoblastic leukemia secondary to a chronic myeloproliferative neoplasm Miriam AlbAcniz1, A Molina2, Maite Serrando2, JosAc Luis Bedini2, Anna Merino2. 1Biochemistry and Molecular Genetics Department, Biomedical Diagnostic Centre (CDB), Hospital ClAsnic, Barcelona, Spain.2Core Laboratory, Biochemistry and Molecular Genetics Department, Biomedical Diagnostic Centre (CDB), Hospital ClAsnic, Barcelona, Spain

172

Automatic identification of acute myeloid leukemia with nucleophosmin gene mutation using a vision transformer-based artificial intelligence model Kevin Barrera2, Anna Merino1, JosAc Rodellar3. 1CORE Laboratory. Biochemistry and Molecular Genetics Department. Biomedical Diagnostic Center. Hospital Clinic, Barcelona, Spain.2Control, Data and Artificial Intelligence (CoDAlab), Department of Mechanical Engineering, Escola da, Barcelona, Spain.3Control, Data and Artificial Intelligence (CoDAlab), Department of Mathematics, Escola da, Barcelona, Spain

173

Pediatric Erythroblastic Sarcoma: A Unique Hematopoietic Neoplasm with CNS Tropism and NFIA Fusions. Mira/G Basuino1, Anton Rets1, Jeffrey Jacobsen1, Peng Li1, Maria Aguiar2, William Owen3, Linda Pegram3, Madhu Menon1. 1University of Utah and ARUP Laboratories, Salt Lake City, UT, USA.2Children's Hospital of the King's Daughters Department of Pathology, Norfolk, VA, USA.3Children's Hospital of the King's Daughters Department of Hematology and Oncology, Norfolk, VA, USA

174

Integrated Longitudinal Laboratory and Morphologic Assessment for Risk Stratification of Disease Progression in Chronic Lymphocytic Leukemia Yi-Yun Chen1, Chuan-Po Lee1, Hsiang-Ling Ho1, 2. 1Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.2Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

175

From Optical to Digital: Performance Evaluation of the Scopio X100 in Bone Marrow Morphology. Nathan Debunne, Nick Verhavert, Annemie De Craemer, Carolien Bonroy, Barbara Denys, Stijn Lambrecht, Mattias Hofmans. Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium

176

Evaluation of Chemotherapy Induced Erythrocyte Injury Beyond Routine Blood Counts Using Peripheral Blood Smears and MIZAR® Syllectometry Caroline Ding1, Yousif Al-Aboosi1, Lucas Chronis1, Caroline Mwubaha3, Regan Bucciol1, Yousra Tera1, 2, Maha Othman1, 2, 3. 1Department of Biomedical and Molecular Sciences, Queena, Kingston, ON, Canada.2Clinical Pathology Department, Faculty of Medicine, Mansoura, Egypt.3School of Baccalaureate Nursing, St. Lawrence College, Kingston, ON, Canada

177

EVALUATION OF THE NEW CELLAVISION BONE MARROW ASPIRATE APPLICATION FOR MORPHOLOGICAL EXAMINATION AND CLASSIFICATION OF BONE MARROW CELLS JOSE RAMON FURUNDARENA1, ALASNE URANGA1, SARA URRUTIA 1, LOURDES AGUIRREZABALA 1, AMAIA ARAMBARRI 1, NEREA URESANDI 1, NAGORE ARGOITIA 1, LEIRE URRITZA 1, CARLOS BARBARIN 1, CLARA DIEZ 1, SHEILA CARRASCO 1, JESSICA IRANZO 1, JULIA SANTA CATALINA 1, CRISTINA SARASQUETA2, CARLOS MANUEL PANIZO1. 1Hematology Laboratory. Donostia University Hospital., DONOSTIA, Spain.2Clinical epidemiology. Donostia University Hospital., DONOSTIA, Spain

178

Real-World application of Horiba D20 Digital Morphology Analyzer for remote access peripheral blood film reporting and its impact patient management: An experience from a Tertiary Care Hospital Laboratory in India Anil Handoo1, Mudita Bhargava2, Ankur Lath3, Richa Sharma2, Parul Babbar3, Paramjit Kaur3. 1BLK-Max Super Speciality Hospital, Pusa Road, New Delhi, India, New Delhi, India.2Max Super Speciality Hospital, Dwarka, New Delhi, India, New Delhi, India.3Horiba India Pvt Ltd, New Delhi, India

179

Case report: Hematological findings in case of intravascular hemolysis caused by Clostridium perfringens infection UrAika Kramberger, Elizabeta BoA¾nar AliA. University Medical Centre Ljubljana, Institute of Clinical Chemistry and Biochemistry, Ljubljana, Slovenia

180

Evaluation of the hematology digital imaging system Scopio X100HT in a university hospital setting Alina Kuepper, Sladana Nikolic, Michael Spannagl, Michael Weigand, Daniel Teupser, Mathias Bruegel. Institute of Laboratory Medicine, Ludwig-Maximilians-University, Munich, Germany

182

Detection of Monoblasts in Urine in a Patient with Acute Myeloid Leukemia: Integration of Cytology and Next-Generation Sequencing for Diagnosis Carlos MartAsn Alonso, Maite Serrando Querol, Anna Merino, Rosa FernAindez Bonifacio, A Molina Borras, Mari Carmen Salgado. CORE Laboratory, Biochemistry and Molecular Genetics Department, Biomedical Diagnostic Center, Hospital ClAsnic, Barcelona, Spain

183

Early detection of myelodysplastic syndromes and chronic myelomonocytic leukemia with a new model based on transformers and Sysmex-XR cell population data Anna Merino1, Kevin Barrera2, Alex BarragAin1, Angel Molina1, Jose Rodellar2. 1CORE Laboratory. Biochemistry and Molecular Genetics Department. Biomedical Diagnostic Center. Hospital Clinic of Barcelona-IDIBAPS, Barcelolna, Spain.2Technical University of Catalonia, Barcelona, Spain

184

Large Immature Cell (LIC) Parameter Accurately Detects Blast Cells on the Horiba Yumizen H2500 Tri Ratnaningsih1, Lusia Nasrani2. 12Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta Indonesia.2Specialist Medical Education Program in Clinical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta Indonesia

185

Performance Evaluation of an AI-Powered Point-of-Care Hematology Analyzer in a Tertiary Care Setting Tushar Sehgal1, Ashutosh Patra2, Praveen Kumar2, Megha Sharma2. 1Department of Laboratory Medicine, AIIMS, New Delhi, India.2Neuranics Lab, School of International Biodesign, AlIMS, New Delhi, India.3Neuranics Lab, School of International Biodesign, AlIMS, New Delhi, India.4Neuranics Lab, School of International Biodesign, AlIMS, New Delhi, India

186

Detection of Histoplasma sp. during complete blood count analysis in a newly diagnosed HIV patient: a case report supported by artificial intelligence Thulio F. Theodoro1, 2, Camila N. M. Araujo1, 2, Pamela R. V. Figueredo1, Lucas J. C. Ferreira1, Sally C. M. Monteiro2, Rossy-Eric P. Soares1. 1Laboratorio Cedro, Sao Luis, Brazil.2Universidade Federal do Maranhao, Sao Luis, Brazil

187

Functional Hyposplnism post Hematopoietic Stem Cell Transplantation: A Retrospective Analysis Kaori Uchino1, 2, Yuya Nakagami3, Megumi Enomoto3, Yukie Sugita1, 2, Yuto Isaji1, 2, Sakura Saigusa1, 2, Yusuke Iida1, 2, Saki Shinohara1, 2, Tomohiro Horio1, 2, Satsuki Murakami1, 2, Shohei Mizuno1, 2, Kazuhiro Ikegame1, 2, Ichiro Hanamura1, 2, Akiyoshi Takami1, 2. 1Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.2Hematopoietic Cell Transplantation Center, Aichi Medical University Hospital, Nagakute, Japan.3Department of Clinical Laboratory, Aichi Medical University Hospital, Nagakute, Japan

188

NEU-X and NEU-Y obtained with MINDRAY BC-6200 as laboratory markers of inflammation in Emergency Department patients Agnieszka WiA1, 2, MaA Wituska2, Olga Ciepiela1, 2. 1Department of Laboratory Medicine, Medical University of Warsaw, Warsaw, Poland.2Central Laboratory, University Clinical Center of Medical University of Warsaw, Warsaw, Poland

189

Thal-RBCNet: A Lightweight Deep Learning System for Red Blood Cell Morphology Analysis in Thalassemia Vasita Wongsirikul1, Bin Zhao2, Chalisa Parnsamut1, Patrawadee Pitakpolrat1, Hathaiphon Aphaiwiwat1, Parinda Limprasert1, Chutitorn Ketloy1, Phandee Watanaboonyongcharoen1. 1Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok Thailand.2Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen China

190

Establishment of Reference Intervals for Platelet Parameters and Immature Platelet Fraction (IPF) in the Omani Population Musleh Al Musalhi , Abbas Dastani, Shital Parag, Zayad Al Maskari , Yahya Al Rashdi, Ahmed Al Aamri. Ibra Hospital, Ibra, Oman

191

Utility of platelet indexes for Parvovirus B19 diagnosis . Tiffany I. V. BoaventuraLiliana M. S. Otsuka, Alexandre E. Kayano, Newton F. CenturiApo, Erivaldo S. Junior, Andreza O. Santos, Nikolas R. Constantino, Andrea A. R. Villarinho, JoApo C. C. Guerra . Hospital Israelita Albert Einstein, SApo Paulo, Brazil

193

Investigating the utility of whole blood flow cytometry for the assessment of platelet function in patients with normal or low platelet counts Joanne E Joseph1, 2, 3, David E Connor2, 3, David Rabbolini4, Bronwyn Thorp1, 3. 1St Vincent's Hospital, Sydney, Australia.2St Vincent's Centre for Applied Medical Research, Sydney, Australia.3St Vincent's Clinical School, University of NSW, Sydney, Australia.4Kolling Institute of Medical Research, Sydney NSW, Australia

194

The end of the citrate tube in the hematology field? Elise KRATTINGER1, LAco VOISIN1, Nabil CHIOUKH 1Pascale DUSSERT1, Enrico ZULIANI2, Christophe VALLET2, Terence LIANG3, Emilie GEREMIA4. 1HAapital Nord Franche-ComtAc, BELFORT, France.2Menarini Diagnostics France, RUNGIS, France.3Shenzhen Mindray Bio-Medical Electronics Co., Ltd, SHENZHEN, China.4Mindray France, CRETEIL, France

195

Comparison of Automated Platelet Counting Methodologies Against a CD61-Based Immunological Reference Method and Their Potential Impact on Clinical Decision-Making Maria del Mar Meijon1, Beatriz Astibia1, Sandra Lopez1, Fernando Martin1, Miguel Piris1, Juan Marquet1, Javier Lopez1, Jesus Villarrubia2, Gemma Moreno1. 1 Department of Hematology, Hospital Universitario RamA³n y Cajal-IRYCIS, Madrid, Spain.2Laboratorio Central de Madrid/UR Salud UTE, Madrid, Spain

196

Distinction of real thrombocytopenia from false low platelet counts using differently anticoagulated blood Anna-Louisa Paul1, Annika Stueven1, Alexandra Hapke1, Peter Kohlschein1Peter Schuff-Werner1, 2. 1Medical Laboratory Osnabrueck, D-49124 Georgsmarienhuette Germany.2University Medical Center, Institute for Clinical Chemistry and Laboratory Medicine, D-18057 Rostock Germany

197

Primary Analytical Performance Evaluation of the Mindray BC720 Immature Platelet Fraction Parameter (IPFD) Kunal Sehgal, Vasudha Kaul, Pratidnya Parab, Jyotsna Rathod. Sehgal Path Lab, Mumbai, India

198

Assessment of Beliefs, Education and Habits in the Prevention of Sickle Cell Disease among College Students in Osun State: The Need for Genetic Counselling Florence I. Aboderin1, Busayo G. Ologun2, Joshua S. Olajide2, Emmanuel Adepoju1. 1University of Ilesha, Ilesha, Nigeria.2Obafemi Awolowo University, Ile-Ife, Nigeria

199

Haemoglobin Jeddah, A Rare α-globin Variant Highlighting Diagnostic Challenges in Hemoglobinopathy Screening: A Case Series from Oman. Thekra I. Al-Obaidani1, Maha S. Al-Yahyai2, Ghalia Al-Harthi2, Afrah Al-Fulaiti2. 1Oman Medical Specialty Board (OMSB), hematopathology residency program, Muscat, Oman.2The Royal Hospital, Muscat, Oman

200

Assesment of B-Thalassemia trait occurrence in an outpatient sample from southern Chile: A retrospective study. Mario Balcazar, Luis Carrasco, AngAclica Mancilla, Sandra Navia. Tecno-Medic, Puerto Montt, Chile

201

Fast hemoglobin: A sign of alpha thalassemia or a red herring? Melissa Delio1, Christopher Tormey2, Alexa Siddon2. 1University of Colorado Anschutz School of Medicine, Aurora, CO, USA.2Yale School of Medicine, New Haven, CT, USA

202

Sample Stability of a Photometric Rheology-Based ESR Method After Transient Heat Exposure and Return to Room Temperature Steve Giarrusso, Megan McCutcheon. ALCOR Scientific LLC, Smithfield, RI, USA

203

A Digital Transformation of the Kleihauer-Betke Removes the High Coefficient of Variation During the Screening of Fetomaternal Haemorrhage; A Pilot Study Phoebe King1, Riya Raghuram2, Kenneth Salisbury3, Joanna Ward1, Aaron Niblock4, 5. 1School of Engineering, Ulster University, Belfast, United Kingdom.2Department of Engineering, University of Cambridge, Cambridge, United Kingdom.3KAIoptix Ltd., Antrim, United Kingdom.4School of Medicine, Ulster University, Derry, United Kingdom.5Antrim Area Hospital, Antrim, United Kingdom

204

Association of Hematimetric Indices with EMA Binding and Osmotic Fragility in Hereditary Spherocytosis Isabella C. LimaLiliana M. S. Otsuka, Alexandre E. Kayano, Newton F. CenturiApo, Erivaldo S. Junior, Andreza O. Santos, Cristina M. Ito, Andrea A. R. Villarinho, JoApo C. C. Guerra . Hospital Israelita Albert Einstein, SApo Paulo, Brazil

205

ELECTROGLOBINS " Haemoglobin Capillary Electrophoresis: a one year experience Ana Catarina B. Marques , Joana Sevilha, Carla Ferreira , Helena Ferreira da Silva. Clinical Pathology Department, ULS MAcdio Ave, Vila Nova de FamalicApo, Portugal

206

Exploring The Utility of Advanced Red Blood Cell Parameters in Microcytic Hypochromic Anemia Tandry Meriyanti1, 2, Fransisca Probo Setyoningrum2. 1Siloam Hospitals Lippo Village, Banten, Indonesia.2Pelita Harapan University, Banten, Indonesia

207

Prevalence and Clinical Correlates of Anaemia among Hospitalized Geriatric Patients in Malaysia: A Cross-Sectional Study noor haslina mohd noor1, esba ahamed2, maryam azlan2, nurul izzah abdul razak1, asiah nabihah1. 1haematology department, universiti sains malaysia, KUBANG KERIAN Malaysia.2biomedicine department, universiti sains malaysia, KUBANG KERIAN Malaysia

208

Evaluation of the new Mindray H120 instrument for determining HbA1c by HPLC: Comparison of two analysis modes offered by the H-120 with capillary electrophoresis in common situations and in the presence of haemoglobin variants. Stephane Moutereau1, Soraya Fellahi1, Emilie Geremia2Terence Liang3, Jean-Philippe Bastard1. 1DAcpartement de Biochimie-Pharmacologie, HAapital universitaire Henri Mondor, AP-HP INSERM U955, UniversitAc Paris-Est-CrActeil, Creteil, France.2Hematology IVD Product - Mindray France, Creteil, France.3International Scientific Strategy a Partnerships Mindray IVD Division -Shenzhen Mindray Bio-Medical Electronics Co., Ltd, Shenzen, China

209

The rising Prevalence of Elevated Haematocrit in a Large UK Population: A Five Year Retrospective Analysis Toby Nicholson, Ana B. Martins, Andzelika Aydin. Mersey and West Lancashire Teaching Hospitals NHS Trust, Prescot, United Kingdom

210

Pediatric polycythemia: frequent transient finding with few underlying diagnosis Sotirios Papadeas1, 2Yves D Pastore1, 2, 3, 4, Thomas Pincez1, 2, 3, 4. 1CHU Sainte-Justine Azrieli Research Center, Montreal, QC, Canada.2Faculty of Medicine, UniversitAc de MontrAcal, Montreal, QC, Canada.3Division of Pediatric Hematology-Oncology, CHU Sainte-Justine, Montreal, QC, Canada.4RED, RAcseau A, Montreal, QC, Canada

211

When to Suspect Co-inherited alpha-Thalassemia in Common Structural Hemoglobin Variants Armin P. Piehler1, Lea Dewi Schlieben1, Eva C. LangsjAcen2, Gregor Hoermann1, Torsten Haferlach1, Wolfgang Kern1, Manja Meggendorfer1. 1MLL Munich Leukemia Laboratory, Munich, Germany.2FA¼rst Medical Labortory, Oslo, Norway

212

Quantitative reticulocyte changes precede hemoglobinization after short-term oral iron supplementation in regular blood donors Tri Ratnaningsih1, Noor Mukantari2, Fuad Anshori1, Umi S Intansari1, Usi Sukorini1. 1Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta Indonesia.2Medical Specialist Education Program in Clinical Pathology, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta Indonesia

213

Untangling Iron Deficiency from Inherited Microcytosis: The Utility of Ferritin Measurement in Hemoglobinopathy Investigations Nicholas Sandercock1, Jessica Graham1, Barry Eng1, John Waye1, 2, Sarah Patterson1, 3. 11. Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, ON, Canada.22. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.33. Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON, Canada

214

Null α-spectrin mutations in trans with alpha-LELY leading to mild hemolytic anemia; presentation of four cases. Ryan C Shean1, 2, Archana Agarwal1, 2. 1University of Utah Department of Pathology, Salt Lake City, UT, USA.2ARUP Laboratories, Salt Lake City, UT, USA

215

Validation of assay for glucose-6-phosphate dehydrogenase concentration using an automated haemostasis analyser Karen Thompson1, 2, Jude Platton1, 2, George Tarpley1, 2Sophia Katiri1, 2, Andrea Alkins3, Juswal Dadhra1, 2. 1Red Cell Laboratory, Royal London Hospital, London, United Kingdom.2National Health Service East and South East London Pathology Partnership, London, United Kingdom.3Sysmex UK, Milton Keynes, United Kingdom

216

Reticulocyte Volume (MRV) reported by Mindray BC8600 + in the study of iron deficient erythropoiesis Eloisa Urrechaga, Eugenia Axpe, Andrea Nieto, Julen Madrazo. Hospital Universitario Galdakao Usansolo, Galdakao, Spain

217

Comparison of ESR measurement results obtained using the modified Westergren method and an alternative method integrated into a hematology analyzer Malkov Vladimir, Kolupaev Vsevolod. Scientific and Practical Center for Laboratory Research of the Moscow City Health Department, Moscow Russia

218

Superior Performance of a Novel Thalassemia Screening Model Over Traditional Indices Using Automated Hematology Analyzers Ping Yin, Jialin TanHonghai Hong. Department of Clinical Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

219

Hypo-He and MicroR as Early Indicators of Iron Deficiency in First-Trimester Pregnant Women: Beyond Ferritin and Transferrin Saturation Razan Hayati Zulkeflee1, Rosline Hassan1, Zefarina Zulkafli1, Shafini Mohamed Yusoff1, Wan Nor Fazila Hafizan Wan Nik2, Nur Hidayah Mohd Fauzi3, Anees Abdul Hamid4, Munira Mahmud4, Siti Nur Iman Sofiah Zulkifli5. 1Department of Hematology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.2Department of Chemical Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.3Department of Obstetrics a Gynaecology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.4Primary Care Unit, Kelantan State Health Department, Tingkat 5, Wisma Persekutuan, Jalan Bayam, 15590 Kota Bharu, Kelantan, Malaysia.5Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Skudai, Johor Bharu, Malaysia

220

Benchmarking Large Language Models Against Interpretive External Quality Assessment in Haematological Oncology Ashley Cartwright, Samuel Nti, Stuart Scott. UK NEQAS for Leucocyte Immunophenotyping, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

221

AN ITALIAN PROJECT AIMED AT HARMONIZING HEMATOLOGY REPORTING: NAVIGATING THROUGH INNOVATION, DEMANDS AND REQUIREMENTS OF A CHANGING WORLD Anna Maria Cenci, Marco Moretti, Sofia Chiatamone Ranieri, Barbara Casolari, Fabrizio Papa, Elisa Piva, Maria Lorubbio. On behalf of Italian Society of Pathology and Laboratory Medicine Hematology Working Group (SIPMeL GdS-E), Castelfranco Veneto (TV), Italy

222

Verification of results comparison between several hematology analyzers, through the EP31-A-IR CLSI guideline Xavier Tejedor GanduxAc1, Fernando Marques Garcia2, Cristina MartAsnez Bravo1, Jennifer RodrAsguez DomAsnguez1, Alba Leis Sestayo1, Isabel Aparicio Calvente1, Alicia Martinez Iribarren1. 1Laboratory Medicine Department. Germans Trias i Pujol Hospital, Badalona Spain.2Laboratory Medicine Department. Donostia Universitity Hospital, Donostia Spain

223

A Retrospective Evaluation of a Web-Based Myelodysplastic Syndrome Predictive Calculator in a Tertiary Hospital in Singapore Frederick M. Ilagan, Kieren Lenin Cheng, Vishnu Prasad. Khoo Teck Puat Hospital, Singapore, Singapore

224

Impact of Moderated Calibration Factor Application on Quality Control Behavior in a High-Throughput Hematology Analyzer Hyun Lee1, 2, Yoonhwan Chang1. 1Seoul National University Hospital, Seoul South Korea.2Dankook University College of Health Sciences, Chungnam South Korea

225

Improving Peripheral Blood Slide Review with CellaVision Digital Hematology Microscopy Zahra Madani, Gabe Fellows, Lauren Namovic, Jan DiGiacinto, Tina IshiiJiehao Zhou. Mayo Clinic Arizona, Phoenix, AZ, USA

226

Evaluation of Criteria Used to Define Allowable Intervals in External Quality Assessment Programs for Hematology Measurands Yutaka Nagai1, 2, Tomohiro Takeda2, Sayaka Mori3, Kazuto Tsuruda3, Hiromitsu Matsushita1. 1Keio University School of Medicine, Tokyo, Japan.2Kansai University of Health Sciences, Osaka, Japan.3Nagasaki University Hospital, Nagasaki, Japan

227

Leveraging process mining to compare platelet usage practices and wastage within a health care network Andreea/M Palage1, Calvino Cheng2, Neal Callaghan3, Jason Quinn2, Natalie Chisholm2, Robert Liwski2. 1Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.2Department of Pathology and Laboratory Medicine, Division of Hematopathology, Halifax, NS, Canada.3Department of Medicine, Division of Internal Medicine, Halifax, NS, Canada

228

Applying indirect approaches to define Hematology and Cell Population Data reference intervals in a Spanish population Alvaro Piedra-Aguilera, Alba Leis-Sestayo, Jennifer Rodriguez-Dominguez, Isabel Aparicio-Calvente, Cristian Morales-IndianoAlicia Martinez-Iribarren. Laboratory Medicine Department. Germans Trias i Pujol University Hospital, Badalona, Spain

229

The Artificial Intelligence challenge: Assessing Diagnostic Quality of Large Language Models Christian Pohlkamp, Christopher Maier, Benjamin Braun, Sven Maschek, Torsten Haferlach, Vivian WA¼rf. MLL Munich Leukemia Laboratory, Munich, Germany

230

Implementation and Evaluation of a Peripheral Blood Morphology External Quality Assessment Program in South Africa Elise Schapkaitz1, 2, Sarvashni Moodliar1, Bongiwe Mofokeng1, Mandisa Zikhali1, Thendo Ramaliba 1. 1Department of Quality Assurance, National Health Laboratory Service, Johannesburg, South Africa.2Department of Hematology, University of Witwatersrand Medical School, Johannesburg, South Africa

231

Impact of heat block drying on morphology of peripheral blood smears Ryan C Shean1, 2, Nicolas Mavromatis1, 2, Gary Isom2, Angie Turnbow2, Lauren Pearson1, 2. 1University of Utah Department of Pathology, Salt Lake City, UT, USA.2ARUP Laboratories, Salt Lake City, UT, USA

232

Enhancing Clinical Excellence: A Comparative Analysis of National and International External Quality Assessment Programs. Marco Stillavato1Anna Maria Massobrio1, Emiliano Carmelo Sartania2, Marco Zompa2, Huijing Hu2, Vincenzo David Russo3, Tiziana Francisci2. 1Clinical Biochemistry-CittAn della salute e della Scienza PO OIRM, Torino Italy.2Blood Bank -CittAn della salute e della Scienza, Torino Italy.3Analytical Development-SITLab, Torino Italy

233

Development of a cell culture model for studying monocytopoiesis: impact of TET2 gene mutations on monocyte maturation Lucy LOCHER1, 2, BAcrAcnice SCHELL1, 2, Jules CRETIN2, Sihem TARFI1, 2, Lydia ROY2, 3, Valeria BISIO4, Nicolas DULPHY4, 5, Ivan SLOMA1, 2Orianne WAGNER-BALLON1, 2. 1Department of Biological Haematology and Immunology, Henri Mondor Hospital APHP, Creteil France.2INSERM Unit 955, UniversitAc Paris Est CrActeil, Creteil France.3Department of Clinical Haematology, Henri Mondor Hospital APHP, Creteil France.4UniversitAc Paris CitAc, Institut de Recherche Saint Louis, INSERM UMR1342, Paris France.5Laboratory of Immunology and Histocompatibility, Saint-Louis Hospital APHP, Paris France